Hyponatremia is the most common electrolyte disorder,occurring in up to 30% of hospitalized patients (1).The most frequent cause of hyponatremia is the syndrome of inappropriate antidiuresis (SIAD),followed by hyponatremia associated with depletion of the effective arterial blood volume (EABV).Many cases remain asymptomatic.However,a careful diagnostic workup of the cause of hyponatremiaPatients and MethodsResultsDiscussionAcknowledgmentsAbbreviationsStudy design and populationBetween April and November 2007,all consecutive hyponatremic patients presenting at the Medical Department of the University of Wurzburg,a 300-bed secondary and tertiary care university hospital,were screened.Eligibility criteria were a serum Na concentration of less than 130 mmol/liter on admissiLaboratory assessmentBlood samples and urine specimens were taken between 1000 and 1300 h (25 h after drug administration).Biochemical evaluation included the venous sampling of serum glucose,urea,creatinine,UA,Na,potassium,chloride,total proteins,albumin,triglycerides,osmolality,cortisol,ACTH,plasma reData analysisCharacteristics of study participants are presented as means with their sd values for normally distributed variables,medians with 25th to 75th percentile for nonnormally distributed variables,and frequencies for categorical variables.Mean values were compared by the Kruskal-Wallis test among different groups.See more on academic.oupCited by 154Publish Year 2008Author Wiebke Fenske,Stefan Störk,Ann-Cathrin Koschker,Anne Blechschmidt,Daniela Lorenz,Sebastian WortPublished Aug 01,2008Value of fractional uric acid excretion in differential Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics FE-UA allows the diagnosis of SIAD with excellent specificity.Combining the information on U-Na and FE-UA leads to a very high diagnostic accuracy in hyponatremic patients with and without diuretic treatment. results for this questionHow is fractional excretion of urea related to renal failure?How is fractional excretion of urea related to renal failure?Fractional Excretion of Urea (FEUrea) Determines the cause of renal failure.Similar to the FENa,but can be used on patients on diuretics.Favorite.Pearls/Pitfalls.While lesser known than FENa,the FEUrea can be used in patients on diuretics,since urea excretion is not significantly affected by diuretics.Fractional Excretion of Urea (FEUrea) - MDCalc results for this questionWhat is a fractional excretion?What is a fractional excretion?Fractional excretions are indexes of renal function that are helpful in evaluating specific clinical conditions.Conceptually,a fractional excretion is the fraction of the filtered substance that is excreted in the urine.Excretion Fraction - an overview ScienceDirect Topics
FEUa > 10% (> 0.1 fraction) indicates SIADH or renal causes.FEUa < 10% (< 0.1 fraction) indicates prerenal causes.See Renal Failure Diff.Diagnosis MultiCalx for more about ARF (acute renal failure) differential diagnosis.Equation Parameters (Fractional Excretion of Uric acid) Links toAzotemia Differential Diagnoses - Medscape ReferenceApr 24,2020·Fenske W,Stork S,Koschker AC,et al.Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics.J Clin Endocrinol Metab.2008 Aug.93(8):2991-7..Liu KD,Matthay MA,Chertow GM.Evolving practices in critical care and potential implications for management of acute kidney injury.
DiagnosisPathophysiologyClinical significanceEvolutionCausesSigns and symptomsFor the initial evaluation,obtain a complete blood count (CBC),a biochemical profile,urinalysis,and urine electrolyte concentrations.In addition to establishing the presence of systemic disease,these tests may reveal clues to the origin of the azotemia.Diagnostic indices are commonly used to differentiate prerenal azotemia from intrarenal or postrenal azotemia (see in the image below).In patients with long-standing CKD,renal ultrasonography usually shows small,contracted kidneys.Some causes of CKD can be assSee more on emedicine.medscapeFractional Excretion of Urea (FEUrea) - MDCalcThe Fractional Excretion of Urea (FEUrea) determines the cause of renal failure.Similar to the FENa,but can be used on patients on diuretics.This is an unprecedented time.It is the dedication of healthcare workers that will lead us through this crisis.Thank you for everything you do.Cited by 10Publish Year 2016Author Louis J.Imbriano,Joseph Mattana,James Drakakis,John K.MaesakaTen common pitfalls in the evaluation of patients with Apr 01,2016·Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics J Clin Endocrinol Metab ,93 ( 2008 ) ,pp.2991 - 2997 CrossRef View Record inCited by 123Publish Year 2014Author Sahar A.Fathallah-Shaykh,Monica T.CramerFractional excretion of trace lithium and uric acid in The effectiveness of the fractional excretion of uric acid (FEUA) and that of endogenous lithium (FELi) in the diagnosis of acute renal failure has been evaluated in an unselected group of 46 patients,28 with prerenal azotemia and 18 with ATN.In the entire group,FELi concurred with the clinical diagnosis in 78% of the patients,whereas the
Value of Fractional Uric Acid Excretion in Differential Diagnosis of Hyponatremic Patients on Diuretics Wiebke Fenske,* Stefan Sto¨rk,* Ann-Cathrin Koschker,Anne Blechschmidt,Daniela Lorenz,Sebastian Wortmann,and Bruno AllolioCited by 1Publish Year 2020Author Vincenzo Bassi,Olimpia FattorusoAltmetric Value of Fractional Uric Acid Excretion in Value of Fractional Uric Acid Excretion in Differential Diagnosis of Hyponatremic Patients on Diuretics Overview of attention for article published in The Journal of Clinical Endocrinology Cited by 1Publish Year 2020Author Ying Xu,Xun Zhou,Yuqi Zheng,Haochen Guan,Chensheng Fu,Jing Xiao,Zhibin YeUric acid and the kidney - Home - SpringerAbstract Uric acid,the end product of purine metabolism,is excreted predominantly by the proximal tubules.Abnor-mal serum levels of uric acid are due to alterations in pro-duction or excretion.Fractional excretion of uric acid is help-ful in determining the underlying etiology of hypouricemia or hyperuricemia in children.
Fenske W,Störk S,Koschker AC,Blechschmidt A,Lorenz D,Wortmann S,Allolio B Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics.J Clin Endocrinol Metab.2008,93:2991-2997.10.1210/jc.2008-0330Differentiating between SIADH and CSW Using Fractional Salt Wasting,Fractional Excretion of Uric Acid,Fractional Excretion of Phosphate 1.Introduction Hyponatremia is one of the most frequently encountered electrolyte imbalances observed in both neurosurgical patients as well as patients in the acute care set-ting.It is commonly associated with traumatic brain injuries (TBI) or otherExcretion Fraction - an overview ScienceDirect TopicsThe fractional excretion of sodium (FE Na) reflects the percent of filtered sodium that is excreted in the urine.The filtered sodium load can be determined from the product of the GFR and the P Na.Since GFR is often not available,the FE Na can be derived as follows (Eq.1)FE Na ( %) = U Na × V / GFR × P Na.
Fenske,W.,Stork,S.and Koschker,A.C.(2008) Value of Fractional Uric Acid Excretion in Differential Diagnosis of Hyponatremic Patients on Diuretics.The Journal of Clinical Endocrinology Metabolism,93,2991-2997.File Size 467KBPage Count 10UpToDateFenske W,Störk S,Koschker AC,et al.Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics.J Clin Endocrinol Metab 2008; 93:2991.Bassi V,Fattoruso O.The Role of Fractional Excretion of Uric Acid in the Differential Diagnosis of Hypotonic Hyponatraemia in Patients with Diuretic Therapy.Fractional Excretion Of Uric Acid Reference Rangereceive our scientific events.Fractional uric acid excretion in differential diagnosis of fractional of uric acid reference range laboratory in differential diagnosis of hyponatremic patients with viapath group llp.Differential diagnosis of fractional uric acid excretion acid reference range for clinical advice or renal and prerenal arf.
Feb 10,2021·Fenske W,Störk S,Koschker A-C,et al.Value of Fractional Uric Acid Excretion in Differential Diagnosis of Hyponatremic Patients on Diuretics.J Clin Endocrinol Metab.2008; 93 (8) p.2991-2997.doi 10.1210/jc.2008-0330 .Open in Read by QxMD; Ellison DH,Berl T.The Syndrome of Inappropriate Antidiuresis.Identifying Different Causes of Hyponatremia With Methods We used an algorithm that relies on fractional excretion of urate (FEurate) to evaluate patients with hyponatremia and present 4 illustrative cases.Results Overall,2 patients had increased FEurate [normal 4-11%],as is seen in SIADH and RSW.A diagnosis of SIADH was made in 1 patient by correcting the hyponatremia with 1.5% saline and observing a characteristic normalization of anRelated searches for value of fractional uric acid excretion ifractional excretion of uric acid calculatorfractional excretion uric acid hyponatremiaexcretion of uric aciduric acid excretion calculationfractional excretion of uratefractional excretion of ureafractional excretion of calciumfractional excretion of calcium calculatorSome results are removed in response to a notice of local law requirement.For more information,please see here.12345Next
·Inefficient renal excretion of uric acid is the main pathophysiological mechanism for hyperuricemia in gout patients.Polymorphisms of renal tubular transporters linked with sodium and monosaccharide transport have yet to be demonstrated.We intended to evaluate the impact of insulin resistance,evaluated with the homeostasis model assessment (HOMA),through a transversal studyRenal underexcretion of uric acid is present in patients Dec 12,2002·Clearance of uric acid was calculated from the formula Cur = Uv Uur/Sur,expressed in ml/min (where Uur is urinary uric acid and Sur is serum uric acid).Fractional excretion of uric acid was calculated as FEur = (Uur × Scr)/(Sur × Ucr) × 100,expressed as percentage.The Role of Fractional Excretion of Uric Acid in the Download Citation The Role of Fractional Excretion of Uric Acid in the Differential Diagnosis of Hypotonic Hyponatraemia in Patients with Diuretic Therapy Hyponatraemia is the most common
Feb 15,2020·1.Clin Hypertens.2020 Feb 15;26:4.doi 10.1186/s40885-020-0136-6.eCollection 2020.The association of urinary uric acid excretion with ambulatory blood pressure values in patients with chronic kidney disease.UpToDateRisksResearchChemistryAs described below,there are a number of limitations to the use of FENa in patients with AKI.These limitations include the variability of the threshold FENa that is used to define prerenal disease,the presence of multiple causes of a low FENa other than prerenal disease,and errors associated with the use of measures of sodium excretion in the setting of renal salt wasting (as with diuretic therapy).Thus,the etiology of AKI should be based upon the totality of the presentation (history,clinical examination,uSee more on uptodateClinical Laboratory Evaluation of the Syndrome of This finding suggests that expansion of the extracellular volume was responsible for the increase in fractional uric acid excretion.The increase in uric acid fractional excretion in the SIADH is due to a decrease in tubular reabsorption ( 42 ),mainly localized at presecretory and postsecretory sites of the tubule,whereas urate secretion Value of Fractional Uric Acid Excretion in Differential SIAD group (n = 31).Non-SIAD group (n = 55).Age (yr) 66 (15) 70 (15) Female sex (%) 17 (55) 32 (58) Current diuretic therapy 15 (48%) 42 (76%)
Value of Fractional Uric Acid Excretion in Differential Diagnosis of Hyponatremic Patients on Diuretics May 2008 Journal of Clinical Endocrinology Metabolism 93(8):2991-7Value of fractional excretion of urate in differential between fractional excretion of urate [FEurate],serum sodium,and distinctive responses to saline infusions to differentiate SIADH from other causes of hyponatremia without the need to consider the volume status of patients or determinations of urine sodium,plasma renin,uric acid,or aldosterone serum levels (14,15).Value of fractional uric acid excretion in differential Its diagnosis requires decreased serum osmolality,inappropriately diluted urine (e.g.>100 mOsm/kg),clinical euvolemia,and a urinary sodium (Na) excretion (U-Na) more than 30 mmol/liter.
Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics.Fenske W; Störk S; Koschker A; et al.See more; Journal of Clinical Endocrinology and Metabolism (2008) 93(8) 2991-2997.DOI 10.1210/jc.2008-0330.113 Citations.Citations of this article.Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics FE-UAallows the diagnosis of SIAD with excellent specificity.Combining the information on U-Na and FE-UA leads to a very high diagnostic accuracy in hyponatremic patients with and without diuretic treatment.Cited by:154Publish Year:2008Reference pubmed.ncbi.nlm.nih.gov/18477658/Was this helpful?People also askHow is fractional uric acid excretion used to diagnose Siad?How is fractional uric acid excretion used to diagnose Siad?Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics FE-UA allows the diagnosis of SIAD with excellent specificity.Combining the information on U-Na and FE-UA leads to a very high diagnostic accuracy in hyponatremic patients with and without diuretic treatment.Value of fractional uric acid excretion in differential diagnosis of What is the pathophysiology of prerenal azotemia?Jun 05,2020·Fenske W,Stork S,Koschker AC,et al.Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics.J Clin Endocrinol Metab .
Fenske W,Stork S,Koschker AC,et al.Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics.J Clin Endocrinol Metab .2008 Aug.93(8):2991-7
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